Click Here to Subscribe: http://Bit.ly/ThomasVid
Website: http://ThomasDeLauer.com

Get the Apparel I Wear at www.http://Hylete.com

Basics of Fat Loss | Simple Science that You can Use – Thomas DeLauer

HSL

Hormone sensitive lipase is a complex chemically structured enzyme that acts as a catalyst for the hydrolysis of fat in your body

The levels of hormone-sensitive lipase (HSL) in your body are inversely proportional to the serum levels of insulin – what this means is that as the levels of HSL decrease, the insulin levels in your blood increase

Simply put, it’s what burns your fat deposits

The only site for regulation of fatty acid oxidation is at the level of hormone-sensitive lipase in adipose tissue (more later)

Under fasting conditions, with minimal insulin in the blood, glucagon promotes formation of the phosphorylated, active form of hormone-sensitive lipase

When epinephrine is present, it further shifts the equilibrium to active hormone-sensitive lipase, increasing the hydrolysis of triglycerides to produce free fatty acids (FFA) and glycerol

The glycerol is carried to the liver, where it enters gluconeogenesis, while the FFA are carried on serum albumin to the tissues where they are catabolized for energy

The liver uses some of the energy from fat mobilization to support gluconeogenesis

Adipose Triglyceride Lipase

Hormone-sensitive lipase (HSL) was the first lipase known to hydrolyze triacylglycerols in rat adipose tissue (1988) until the identification of adipose triglyceride lipase (ATGL) in 2004

While HSL could catalyze the hydrolysis of triacylglycerides and diacylglycerides as well as various cholesterol ester species, ATGL showed high substrate specificity for triacylglycerides

To date, three major lipases have been identified: Adipose triglyceride lipase (ATGL) performs the first step of TG hydrolysis, generating diglycerides (DGs) and FAs

Hormone-sensitive lipase (HSL) performs the second step and hydrolyzes DGs, generating monoglycerides (MGs) and FAs

In contrast to ATGL, HSL exhibits a broader substrate specificity, also hydrolyzing TGs, cholesteryl esters, MGs, and retinyl esters in addition to DGs

Monoglyceride lipase (MGL) is selective for MGs and generates glycerol and the third FA – thus, lipolysis constitutes a coordinated three-step process catalyzed by three different enzymes, which degrade TG into glycerol and FAs

End

Hormone-sensitive lipase (HSL) is presumed to be essential for lipolysis, which is defined as the mobilization of free fatty acids from adipocytes

Lipolysis is under the control of various hormones and cytokines in adipocytes – Lipolytic hormones such as catecholamines and ACTH stimulate cAMP-dependent protein kinase (PKA), which in turn phosphorylates hormone-sensitive lipase (HSL) and perilipin in adipocytes

References

1) Hormone-Sensitive Lipase – an overview | ScienceDirect Topics. (n.d.). Retrieved from https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/hormone-sensitive-lipase
2) Hormone-sensitive lipase. (n.d.). Retrieved from http://www.jlr.org/content/43/10/1585.full
3) Ruiz G , et al. (n.d.). Cyclic AMP-dependent protein kinase activity and lipolysis in adipose tissue. Effect of fasting, oligomycin and iodoacetamide. – PubMed – NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/6280256
4) What is Hormone-Sensitive Lipase? (n.d.). Retrieved from https://bodytomy.com/hormone-sensitive-lipase
5) Lipolysis in the Absence of Hormone-Sensitive Lipase. (2002, December 1). Retrieved from http://diabetes.diabetesjournals.org/content/51/12/3368
6) Perilipin – an overview | ScienceDirect Topics. (n.d.). Retrieved from https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/perilipin
7) Perilipin Promotes Hormone-sensitive Lipase-mediated Adipocyte Lipolysis via Phosphorylation-dependent and -independent Mechanisms. (n.d.). Retrieved from http://www.jbc.org/content/281/23/15837.full
8) The Phosphorylation of Serine 492 of Perilipin A Directs Lipid Droplet Fragmentation and Dispersion. (n.d.). Retrieved from http://www.jbc.org/content/281/17/11901.full
9) Elkins DA and Spurlock DM. (n.d.). Phosphorylation of perilipin is associated with indicators of lipolysis in Holstein cows. – PubMed – NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/19585405
10) Schweiger M , et al. (n.d.). Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism. – PubMed – NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/17074755
11) Kershaw EE , et al. (n.d.). Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin. – PubMed – NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/16380488
12) Adipose Triglyceride Lipase – an overview | ScienceDirect Topics. (n.d.). Retrieved from https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/adipose-triglyceride-lipase

Share this page:

Are there any ways to lose weight besides diet and exercise? There are many tricks that can help you lose a bit of excess weight in just 2 weeks. We’re going to share with you 15 tips that can help you get rid of excess belly fat. Most people don’t even know about these tricks!

Science proves that people burn less fat when they sleep during the day and are active at night. A group of researchers from the University of Colorado studied 14 healthy people for 6 days.
During the first 2 days, subjects slept during the night and didn’t have daytime naps. Then they changed their sleeping patterns to imitate owls’ sleeping schedules. It turned out that when people took a nap, their metabolism worsened since their biological clocks didn’t completely flip to fit their schedules.

TIMESTAMPS:
Avoid sugary drinks 1:01
Drink green tea 1:28
Hide unhealthy foods 1:47
Brush your teeth more often 2:20
Laugh more! 2:57
Drink more water 3:36
Follow the 2.5-minute rule 4:15
Eat less but more often 4:57
Remove the bright blue light from electronic displays 5:36
Stop counting calories 6:20
Let cool air into your bedroom 6:58
Forget about daytime sleep 7:37
Once a week, break your diet deliberately 8:20
Get rid of stress 8:52
Get plenty of sleep 9:20

#loseweight #weightlosstips

Music by Epidemic Sound https://www.epidemicsound.com/

SUMMARY:
– When your sweet tooth kicks in, you’re often tempted to chug a can of soda or some fruit juice. However, if you’re determined to lose weight, this sugary addiction must stop.
– According to Dr. Margriet Westerterp-Plantenga of Maastricht University, drinking green tea may help because it’s loaded with antioxidants called catechins, which enhances its fat-burning capabilities.
– According to a study by scientists at Ohio State University, you crave unhealthy snacks more when they’re within your reach.
– Brushing doesn’t only clean your teeth! It can also help in the fight against excess weight if you brush during the day.
– Sincere laughter uses about the same amount of energy as walking since it involves different muscles, especially abdominal ones.
– The thing is, 5–30 seconds of hard exercise during a workout (for example, speeding up while riding a bike or running on a treadmill) with 4-minute breaks may increase your metabolism, and you’ll burn an extra 200 calories.
– When you eat frequently, you let your body know that there’s no need to accumulate fats. When we skip a meal, we send the opposite signal — and we tend to eat more.
– Anthropology at Kyushu University showed that bright light confuses our brain, which then stops producing melatonin. Our metabolism is tightly connected to our sleeping patterns and the amount and quality of our sleep.
– Nutritionists recommend that you stop focusing on calories and pay more attention to the quality of the products you eat since not all calories are equal.
– Сool temperatures in a room influence brown fat (a fat layer that protects the body from freezing). As a result, it splits white fat and burns chemical energy to create heat.
– Science proves that people burn less fat when they sleep during the day and are active at night.
– According to a study from Ohio State University, stress slows down our metabolism. What’s more, when we’re stressed out, we tend to eat more greasy, sweet, and salty foods.
– A healthy 8 hours of sleep (from 10 PM/11 PM to 6 AM/7 AM) contributes to great metabolism. It can also help you get rid of unwanted belly fat.

Subscribe to Bright Side : https://goo.gl/rQTJZz

—————————————————————————————-
Our Social Media:

Facebook: https://www.facebook.com/brightside/
Instagram: https://www.instagram.com/brightgram/

5-Minute Crafts Youtube: https://www.goo.gl/8JVmuC

—————————————————————————————-
For more videos and articles visit:
http://www.brightside.me/
Video Rating: / 5

Share this page:

Thank you for checking out my Hydroxycut Black Intense Weight Loss Supplement Review. I hope this video helped you guys out. Remember to comment below if you have any questions.

Pick Up Your Own Pick up Hydroxycut Black Weight Loss Supplement Here: http://bit.ly/2LtSlGL

Benefits of Hydroxycut Black Weight Loss Supplement
-Fat Loss
-Weight Loss
-Energy

Hydroxycut Black Weight Loss Supplement Ingredients
-Caffeine Anhydrous 200mg
-Robusta Coffee Extract 200mg
-Alpha Lipoic Acid 150mg
-Yohimbe Extract
-Black Caraway Extract
-Purslane Extract
-Arugula Extract
-Chicory Extract

Again, thanks for coming by to check out my Hydroxycut Black Weight Loss Supplement Review

Browse my site for other products, reviews, and the best place to buy supplements online Https://everythingcreatine.com
———————————————————————————————————–
The Gym Rat World is dedicated to bringing you the best unbiased no BS reviews of supplement products. The Gym Rat World will be bringing you reviews of pre workout, reviews of post workout, and reviews of protein supplements. The Gym Rat World gives reviews on all major brands such as MusclePharm, Cellucor, Optimum Nutrition, Beast Sports, and many more. We deliver only the best for you and we are striving to improve on a daily basis.
Come Be Awesome With Us And Follow The Gym Rat World. The best spot to buy supplements online.

Get ALL of my Top 5 Supplement Lists (Pre Workouts, Proteins, BCAA’s, and More) Directly On Amazon Here: https://www.amazon.com/shop/thegymratworld
Instagram: https://www.Get ALL of my Top 5 Supplement Lists (Pre Workouts, Proteins, BCAA’s, and More) Directly On Amazon Here: https://www.amazon.com/shop/thegymratworld
Instagram.com/thegymratworld
Twitter: https://twitter.com/Thegymratworld
Facebook: https://www.facebook.com/The-Gym-Rat-World

——————————————————————————————————-
Check Out Our Other Social Media Awesomeness

Get ALL of my Top 5 Supplement Lists (Pre Workouts, Proteins, BCAA’s, and More) Directly On Amazon Here: https://www.amazon.com/shop/thegymratworld
Instagram: https://www.Get ALL of my Top 5 Supplement Lists (Pre Workouts, Proteins, BCAA’s, and More) Directly On Amazon Here: https://www.amazon.com/shop/thegymratworld
Instagram.com/everythingcreatine/
Twitter: https://twitter.com/AllCreatine
Facebook: https://www.facebook.com/Everything-Creatine
Tumblr: https://www.tumblr.com/blog/everythingcreatine
Pinterest: https://www.pinterest.com/AllCreatine/

—————————————————————————————————–
https://thegymratworld.com
#Supplementreview #Supplement

Share this page:

Now you can Train with Sunny!

Join Online Coaching!/Training!
http://mybollywoodbody.com/index.php/training

Another great question answered. We give you simple steps on how to lose stomach Fat Fast. Expert Advice. How do you lose stomach fat. Why you are not losing it. We explain how your body burns fat and from where, what do you lose first etc. We talk about simple steps in your diet and simple steps in your workout. We talk about men and women. We also talk about how to access your body, how to keep track of your progress.
#MyBollywoodBody #iKnowSUNNY

A fully comprehensive answer to very common questions asked daily. BEST VIDEO to answer your question.

Check out this video and find why you are not losing weight. All answered in this video. If you have any more questions you want answered ask us in the comments below.

Share your feedback in the comments.

This video also has english subtitles. Click on Closed Caption button to see english subtitles.

Make sure to | COMMENT | LIKE | SHARE |

Here are more diet plans for Fat Loss as well:

Here is a Top 5 Fat loss tips video:

Here is a Fat Loss Diet Plan:

Here is a Fat Loss Vegetarian Diet Plan:

Trick to Lose Face Fat:

All diet plans are in Diet Plan Playlist:

***Find 100’s of videos in our Playlists!***

Visit our website: http://www.mybollywoodbody.com

https://www.facebook.com/mybollywoodbody
Tweets by MYBOLLYWOODBODY
https://instagram.com/mybollywoodbody

If you have questions, message us on our Facebook page.

Share this page:

5 Simple Yoga Exercises To Lose Belly Fat At Home In 1 Week | Best Yoga Asanas for Losing Weight Loss Quickly & Easily

Yoga is a group of physical, mental, and spiritual practices or disciplines which originated in ancient India. Yoga means union of the individual consciousness or soul with the Universal Consciousness or Spirit.

The science of Yoga imbibe itself the complete essence of the Way of Life, including – Gyan Yoga or philosophy, Bhakti Yoga or path of devotional bliss, Karma Yoga or path of blissful action, and Raja Yoga or path of mind control. Raja Yoga is further divided into eight parts. At the heart of the Raja Yoga system, balancing and unifying these various approaches, is the practice of Yoga Asana.

#yoga #yogaasana #yogaexercises #weightlossyoga #howtolosebellyfat #howto

Click below to Subscribe to our Channel for Regular Videos! –
http://www.youtube.com/user/learnyogavideos?sub_confirmation=1

To Watch Other Videos on Yoga for Beginners –

Become a LearnYogaVideos Fan on Facebook:
https://www.facebook.com/yogaameditation?ref

Visit our official website!
http://www.musicandchants.com/

Connect with us:
Google+: https://plus.google.com/u/0/b/104688661840125654992/+LearnYogaVideos/posts
Facebook: https://www.facebook.com/superaudiomadras?ref=hl
Twitter: https://twitter.com/musicandchants
iTunes: https://itunes.apple.com/us/artist/super-audio-madras-pvt-ltd/id547539011

Find us on
http://www.pinterest.com/navindaswani5/
Video Rating: / 5

How to Lose Belly Fat Fast. In case you dream of a perfectly toned summer body but don’t have the time and will power to spend hours at the gym or cut on your favorite foods, we have good news for you. This selection of our best videos on how to drop a few pounds and get a flat belly in no time will teach you how to transform your body with just one simple exercise, how to slim down in just 4 weeks without significant efforts and exhausting training. You’ll also find out about 6 different types of body fat based on where on the body it is mainly accumulated and learn the most effective ways to make fat disappear for every body type. It’s also possible to change your dress size to a smaller one without exercise whatsoever if you follow 10 simple tips and try 10 home remedies that’ll cost you no money but give you a tons of health benefits.

TIMESTAMPS
One Simple Exercise to Lose Back and Belly Fat Fast 0:10 https://youtu.be/YFUh7A_wQFs
5 Simple Exercises to Get a Flat Belly in 4 Weeks 6:44 https://youtu.be/q9CNusqSGDY
6 Types of Body Fat and Hot to Get Rid of It 12:30 https://youtu.be/cYYiGxRBy6c
10 Home Remedies to Lose Belly Fat Without Exercise 22:32

7 Easy Exercises for a Flat Stomach and Small Waist 31:40 https://www.youtube.com/watch?v=xop_uIKVS4o

Subscribe to Bright Side : https://goo.gl/rQTJZz

—————————————————————————————-
Our Social Media:

Facebook: https://www.facebook.com/brightside/
Instagram: https://www.instagram.com/brightgram/

5-Minute Crafts Youtube: https://www.goo.gl/8JVmuC

—————————————————————————————-
For more videos and articles visit:
http://www.brightside.me/
Video Rating: / 5

Share this page:

“Famous” Physical Therapists Bob Schrupp and Brad Heineck present How to Lose Belly Fat in ONE Week at Home with 3 Simple Steps

***Update*** The Bob & Brad Workout Wall Anchors are currently available on our website. Order now and get a bonus anchor (for a total of 4)!
Order here: store.bobandbrad.com

Check out the Products Bob and Brad LOVE on their Amazon Preferred Page https://www.amazon.com/shop/physicaltherapyvideo

Make sure to like Bob and Brad on Facebook https://www.facebook.com/BobandBrad

Follow us on Twitter https://twitter.com/PtFamous
Our Website: https://www.bobandbrad.com/

Our book “Three Simple Steps To Treat Back Pain” is available on Kindle https://www.amazon.com/Three-Simple-Steps-Treat-Back-ebook/dp/B00BPU4O5G/ref=sr_1_1?ie=UTF8&qid=1444092626&sr=8-1&keywords=3+simple+steps+to+treat+back+pain

Brad’s Book “Martial Arts Manual: For Stretching, Strengthening, Prevention, and Treatment of Common Injuries” is also available on Kindle. https://www.amazon.com/Martial-Arts-Manual-Stretching-Strengthening-ebook/dp/B0722J3PZL/ref=sr_1_fkmr0_1?ie=UTF8qid=1494292881&sr=8-1-fkmr0&keywords=brad+heineck+martial+arts

WANT TO HELP TRANSLATE OUR VIDEOS? We would so love the help. http://www.youtube.com/timedtext_cs_panel?tab=2&c=UCmTe0LsfEbpkDpgrxKAWbRA

We are a participate in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for us to earn fees by linking Amazon.com and affiliated sites.

Share this page: